Contributions from different intermolecular and interionic forces, as well as variations in bond energies, produce size-dependent variations in the structures of acid-base molecular clusters. In this work the structures and interaction energetics of cluster particles with the nominal formulas (NHX), X = (F, Cl, Br) are predicted using either "mag-walking" sawtooth simulated annealing Monte Carlo calculations or model building, followed by M06-2X or RI-MP2 geometry optimization and single-point energy calculations. Whereas the n = 1 clusters all exhibit a single hydrogen bond, small (NHF) particles (n = 2-5) exhibit three distinct types of hydrogen bonds as a function of size (traditional, ion-pair and proton-shared). However, (NHBr) and (NHCl) particles (n = 2-13) all solely exhibit ion-pair hydrogen bonding, with even values of n exhibiting pronounced relative stability. The computed differential interaction energy of the bromide and chloride systems is generally near the bulk limit of the difference in their accepted lattice energies, despite the fact that their structures do not resemble the bulk crystal structures. Nanoparticle growth reactions are predicted to be thermodynamically spontaneous under standard conditions, with significant size and system dependencies. This work is designed to further our understanding of the nature of hydrogen bonding and other intermolecular forces, particularly within ionic nanocrystallites, as well as the thermodynamics of cluster formation.