This research aimed to establish the factors determining credit accessibility from Microfinance institutions among persons with disabilities in Mombasa County, Kenya. The study was carried out to establish the effect of occupation on credit access from Microfinance Institutions (MFIs) by Persons with Disabilities (PWDs) in Mombasa County. The study tested the hypothesis on the above objectives to enhance the realization of the key factors that constrain credit accessibility by PWDs. The research was anchored on Credit rationing theory, Credit channel theory, and imperfect information theory. The study employed a descriptive survey research design, and a target population of 2037 was used in the study—a study of 204 PWDs. Primary data collection method was employed to gather the required information. The information gathered from this research was analyzed using SPSS V.26. The overall results indicated that all respondents agreed that the independent variable and occupation influenced credit accessibility. Pearson's correlation results indicated a positive relationship between gender, occupation, education, and credit accessibility. The null hypotheses were rejected at a confidence level of 95%. The study findings concluded that greater adoption of occupation greatly affects credit accessibility. The study recommends that National Council for Persons with Disabilities (NCPWD) can use study results to advise PWDs on credit accessibility, promote integration between PWDs and the society around them in Kenya by facilitating the implementation of the existing policies and enhancing development to align with the arising needs of disabled persons.