Presentation and applied case study of a system-wide workflow which supports rapid, systematic and efficient continuous seeded cooling crystallisation process design, with the aim to deliver a robust, consistent process with tight control of particle attributes.

This chapter discusses the fundamental aspects of nucleation and particle formation in the continuous crystallization context, with a main focus on nucleation and crystal growth. The classic crystallization phenomena, fundamental, thermodynamic or kinetic driven, will not be covered here. The primary and secondary nucleation, and some methods of nuclei generation in continuous crystallization are discussed in this chapter. The performance of continuous crystallization processes and challenges with process kinetics and control (such as seeding, mixing, and process dynamics) are also addressed in this chapter.