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The incubation of Reichstein's Compound S (11-desoxy-17a-hydroxycorticosterone) with Cunninyhamella blakesleeana strain H-334 yields 17a-hydroxycorticosterone (Kendall's Compound F, hydrocortisone, Reichstein's Compound M) (Hanson, et al., 1953). The presence of cortisone (11-dehydro-17a-hydroxycorticosterone) in the transformation products was also indicated. This paper will describe some observations on the yields of these two steroids (and other side products) as affected by the addition of various alcohols and of phenol to the fermentation.

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