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h series of 133 2 4 2-pyridyl)-1,2-diarylalkanols, or compounds closely related to them, were synthesized and assayed for their hypocholesteremic and estrogenic activities in rats. Many of these compounds were active in both tests, but there is no necessary correlation between the two effects. Compound 16 was selected for preclinical toxicologic study, followed by a study of its hypocholesteremic effect in man. The compound selected was remarkably nontoxic in all species studied, but it had no hypocholesteremic el'fect in the dog, the monkey, or in man.

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