Retroperitoneal bleeding is a potentially lethal complication of percutaneous intervention, when the common femoral artery is used as vascular access. Surgery, the traditional treatment for this complication in patients with persistent bleeding or hemodynamic instability, carries a considerable risk of morbidity and mortality. We report a case of life-threatening retroperitoneal bleeding successfully treated percutaneously with balloon occlusion and catheter delivery of thrombin to attain thrombosis of a lacerated branch of the common femoral artery. Endovascular catheter-based percutaneous treatment for massive retroperitoneal bleeding is often effective and should be pursued in selected patients.