Angiographic severity of coronary artery stenosis has historically been the primary guide to revascularization or medical management of coronary artery disease. However, physiologic severity defined by coronary pressure and/or flow has resurged into clinical prominence as a potential, fundamental change from anatomically to physiologically guided management. This review addresses clinical coronary physiology-pressure and flow-as clinical tools for treating patients. We clarify the basic concepts that hold true for whatever technology measures coronary physiology directly and reliably, here focusing on positron emission tomography and its interplay with intracoronary measurements.

cally the leading cause of death (Table). The leading causes of death were assault, diseases of the heart, and accidents (Figure, B and Table).Among Hispanic individuals aged 25 to 44 years, COVID-19 was the leading cause of death from March through December 2020 (Figure, C and Table) and during the third and fourth quarters of 2020. During the third quarter, more COVID-19attributed deaths were recorded among Hispanic individuals aged 25 to 44 years than for the next 2 most-common causes combined (accidents and unintentional overdoses).Among White individuals aged 25 to 44 years, COVID-19 was the sixth leading cause from March through December 2020 (Figure , D). The leading causes of death were unintentional overdoses and accidents (Figure, D and Table).Discussion | Results of this cohort study demonstrated that during March through December 2020, the first 10 months of the COVID-19 pandemic in the US, COVID-19 was the second leading cause of death among Black, Hispanic, and White residents of Texas aged 25 to 44 years, and the most common cause during the third quarter of 2020, with a markedly disproportionate increase in mortality among Hispanic residents. One possible explanation may be that Hispanic persons were more likely to be essential workers and, therefore, were less able to avoid exposure to SARS-CoV-2, which has previously been linked to socioeconomic factors. 5,6 Another possible explanation is that Hispanic residents were less likely to have access to primary care and, therefore, more likely to experience unmanaged medical comorbidities associated with worse COVID-19 outcomes. Limitations of this study include the accuracy of data from death certificates and the preliminary nature of 2020 data. Nevertheless, these findings highlight the markedly disparate effects of the COVID-19 pandemic in different populations of young adults, particularly among Hispanic residents of Texas.

BackgroundThe aim of this study was to quantify changes in body composition during ovarian cancer treatment and relate these changes to rates of complete gross resection (CGR).MethodsOne hundred two patients with stage III or IV ovarian cancer who underwent neoadjuvant chemotherapy (NACT) followed by interval debulking surgery were a part of a prospectively collected database that included computed tomography scans at three time points—diagnosis, following NACT, and following debulking surgery. Skeletal muscle, visceral adipose, and subcutaneous adipose tissue volumes were obtained from a 30‐mm volumetric slab beginning at the third lumbar vertebrae.ResultsFollowing NACT, skeletal muscle volume was significantly reduced (352.5 to 335.0 cm3, P < 0.001), whereas adiposity was unchanged. Body mass index (BMI) and skeletal muscle volume were significantly lower in patients who achieved CGR (P < 0.05). When these patients were stratified by BMI, the significant association of skeletal muscle to CGR was limited to patients with a BMI < 25 kg/m2 (P = 0.007).ConclusionSkeletal muscle volume was significantly reduced in patients undergoing NACT for ovarian cancer. Non‐overweight patients were more likely to achieve CGR if they had lower skeletal muscle volume. Use of volumetric‐based measurement for ascertaining body composition should be explored further.

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