Pharmaceutical implants are small sterile solid masses usually cylindrical consisting of a highly potent and purified drug intended to be subcutaneously implanted beneath the skin by suitable special injector or by surgical incision for the purpose of providing the continuous release of the active medicament over a prolonged period of time. The purpose of this study was to evaluate the influence of carnauba wax on the release profile of ibuprofen implants. The implants were prepared with gelatin, hydroxypropyl methylcellulose admixture (80:20) and varying amount of carnauba wax (2.5%, 5%, 7.5%) using the solvent casting technique. Another batch of the implant was formulated without the incorporation of carnauba wax. Glycerin was used as the plasticizing agent. The physicochemical properties and the release kinetics of the implants were evaluated. The implant pellets had a similar appearance with minimal batch to batch variation. The mean diameter/thickness of the implants ranged from 2.46±0.10-2.86±0.03 mm, the percentage drug content was ≤96.92±0.12% and the swelling index values were between 2.68±0.01 -4.87±0.01%. The rate of drug release from the ibuprofen implants was significantly affected by the incorporation of carnauba wax. The higher the amount of carnauba wax incorporated in the formulation, the more retarded the rate of drug release. This can be exploited in the formulation of sustained release ibuprofen implants for the management of chronic diseases such as arthritis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.