ProcThis work describes the synthesis of copper(II) complexes, their identification using spectroscopic and electrochemical methods, structural characterization with X-ray diffraction and density functional theory calculations (DFT), as well as their catalytic activity mimicking that of superoxide dismutase. Structural analysis revealed the formation of complexes with cyclization of ligands L1 and L2 with the formation of a heterocycle, 1,3-oxazolidine. The DFT calculations confirmed this trend by stabilizing with lower energy. In addition, evaluations of mimetic enzymatic activity of complexes C1, C2, C3 and C4 revealed promising IC 50 values compared to other results seen in the literature (IC 50 = 0.22, 0.328, 0.55 and 0.92). Also, calf thymus DNA interactive experiments using UV-visible spectroscopy were conducted in the presence of the copper(II) complexes.

The structural analysis and the SOD-like activity of Cu II complexes [(Cu)(C 16 H 18 N 3 O 5 )]ClO 4 (1) and [(Cu) 4 (C 36 H 52 N 8 O 12 )] (2) are described with ligands obtained from the condensation of picolinaldehyde and 2-formylpyrrole with tris(hydroxymethyl)aminomethane

New mixed‐valence cobalt complexes with ligands derived from pyridoxal were synthesized and characterized, and their application as mimetics of the peroxidase enzyme was investigated. Single‐crystal X‐ray diffraction was used to analyze all complex structures in the solid state and their electrochemical behavior was investigated. A reactivity pattern was observed in the complex synthesis regarding the cobalt compounds from which analogous zwitterionic derivatives were obtained. The importance of these compounds lies in understanding their behavior in an oxidizing environment and evaluating whether they can activate hydrogen peroxide to oxidize phenolic compounds. In nature, enzymes called peroxidases, which efficiently oxidize phenolic compounds, trigger many reactions involving the activation of hydrogen peroxide to oxidize organic substrates. However, these enzymes present several disadvantages, including denaturation and elevated costs. Therefore, these limitations can be overcome by expanding research into the study of synthetic catalysts for the oxidation of phenolic compounds using hydrogen peroxide, which is a highly relevant field of bioinorganic chemistry.