Objectives: To identify the barriers and facilitators for fall prevention implementation in residential care facilities. Design: Systematic review. Review registration number on PROSPERO: CRD42013004655. Data sources: Two independent reviewers systematically searched five databases (i.e. MEDLINE, EMBASE, CINAHL, PsycINFO, and Web of Science) and the reference lists of relevant articles. Review methods: This systematic review was conducted in line with the Center for Reviews and Dissemination Handbook and reported according to the PRISMA guideline. Only original research focusing on determinants of fall prevention implementation in residential care facilities was included. We used the Mixed Method Appraisal Tool for quality appraisal. Thematic analysis was performed for qualitative data; quantitative data were analyzed descriptively. To synthesize the results, we used the framework of Grol and colleagues that describes six healthcare levels wherein implementation barriers and facilitators can be identified. Results: We found eight relevant studies, identifying 44 determinants that influence implementation. Of these, 17 were facilitators and 27 were barriers. Results indicated that the social and organizational levels have the greatest number of influencing factors (9 and 14, respectively), whereas resident and economical/political levels have the least (3 and 4, respectively). The most cited facilitators were good communication and facility equipment availability, while staff feeling overwhelmed, helpless, frustrated and concerned about their ability to control fall management, staffing issues, limited knowledge and skills (i.e., general clinical skill deficiencies, poor fall management skills or lack of computer skills); and poor communication were the most cited barriers. Conclusion: Successful implementation of fall prevention depends on many factors across different healthcare levels. The focus of implementation interventions, however, should be on modifiable barriers and facilitators such as communication, knowledge, and skills. Effective fall prevention must consist of multifactorial interventions that target each resident's fall risk profile, and should be tailored to overcome context-specific barriers and put into action the identified facilitators.© 2017 Elsevier Ltd. All rights reserved.What is already known about the topic? Multifactorial interventions, tailored to each resident's fall risk profile, can reduce the number of falls and recurrent fallers under highly controlled circumstances, but seems to be ineffective under "real-world" conditions, presumably due to poor implementation.Successful implementation of complex, multifactorial interventions in clinical practice involves a tailored, multifaceted approach based on a good understanding of barriers and facilitators for implementation. No reviews exist that comprehensively summarize the evidence on fall prevention implementation barriers and facilitators in residential care settings. What this paper addsSeventeen facilitators and 27 barriers that ...