As the use of medical marijuana expands, it is important to consider its implications for the patient-physician relationship. In Colorado, a small cohort of physicians is recommending marijuana, with 15 physicians registering 49% of all medical marijuana patients and a single physician registering 10% of all patients. Together, they have registered more than 2% of the state to use medical marijuana in the last three years. We are concerned that this dramatic expansion is occurring in a setting rife with conflicts of interest despite insufficient scientific knowledge about marijuana. This system diminishes the patient-physician relationship to the recommendation of a single substance while unburdening physicians of their usual responsibilities to the welfare of their patients.

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not factored into decisions when addressing the treatmentresistant depression. Throughout the book, additional information sources are provided, which I also found to be useful, for instance, the REPROTOX website, recommended in the chapter on treatment-resistant depression during pregnancy.This book provides a useful summary of the current, available literature on evidence-based approaches in managing treatment-resistant depression. Given the prevalence of depression that is resistant to treatment, this book could serve as a good guide for the clinician who feels "stuck" and unable to help his or her patients, especially since such feelings on the part of the clinician are often echoed by the patient.