An analysis of five different datasets of inhibitors of serotonin uptake has yielded quantitative structure/activity relationships (QSARs) which delineate the role of steric and hydrophobic properties essential for inhibition by phenylethylamine-type analogues.

debrisoquine orally on a non-treatment day. Two patients were phenotypically poor metabolisers, but the median metabolic ratio (1.4, range 0.5-10.7) of the extensive metabolisers was significantly (P < 0.01) greater than that of the untreated patients. There was no correlation between the metabolic ratio of an individual patient and the number of PUVA treatments received.We therefore conclude that debrisoquine 4-hydroxylation is not impaired in untreated psoriatic patients. PUVA therapy appears to inhibit debrisoquine metabolism but this requires confirmation in further within-patient studies.

Management and regulatory agencies face a wide range of environmental issues globally. The challenge is to identify and select the issues to assist the allocation of research and policy resources to achieve maximum environmental gain. A framework was developed to prioritize environmental contamination issues in a sustainable management policy context using a nine-factor ranking model to rank the significance of diffuse sources of stressors. It focuses on contamination issues that involve large geographic scales (e.g., all pastoral soils), significant population exposures (e.g., urban air quality), and multiple outputs from same source on receiving environmental compartments comprising air, surface water, groundwater, and sediment. Factor scores are allocated using a scoring scale and weighted following defined rules. Results are ranked enabling the rational comparison of dissimilar and complex issues. Advantages of this model include flexibility, transparency, ability to prioritize new issues as they arise, and ability to identify which issues are comparatively trivial and which present a more serious challenge to sustainability policy goals. This model integrates well as a planning tool and has been used to inform regional policy development.

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