Consideration is given to the convergence of supply chains and sustainability. In doing so, the focus on environmental management and operations is moved from local optimization of environmental factors to consideration of the entire supply chain during the production, consumption, customer service and post-disposal disposition of products. This is a critical and timely topic that captures increasing concerns over sustainability, whether driven by current legislation, public interest, or competitive opportunity. As such, sustainable development is a rich area for academic research that is still in its infancy and has the potential to affect future government policy, current production operations, and identify new business models. This paper provides a background to better understand current trends in this multidisciplinary field that intersect with operations management, and the research opportunities and challenges it presents. #
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Müller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss.
DMV combined with DL is an infrequent but not rare phenomenon. Most patients can be managed with the use of direct or videolaryngoscopy. An easy to use unweighted risk scale has robust discriminating capacity.
Contingency planning is the first stage in developing a formal set of production planning and control activities for the reuse of products obtained via return flows in a closed‐loop supply chain. The paper takes a contingency approach to explore the factors that impact production planning and control for closed‐loop supply chains that incorporate product recovery. A series of three cases are presented, and a framework developed that shows the common activities required for all remanufacturing operations. To build on the similarities and illustrate and integrate the differences in closed‐loop supply chains, Hayes and Wheelwright’s product–process matrix is used as a foundation to examine the three cases representing Remanufacture‐to‐Stock (RMTS), Reassemble‐to‐Order (RATO), and Remanufacture‐to‐Order (RMTO). These three cases offer end‐points and an intermediate point for closed‐loop supply operations. Since they represent different positions on the matrix, characteristics such as returns volume, timing, quality, product complexity, test and evaluation complexity, and remanufacturing complexity are explored. With a contingency theory for closed‐loop supply chains that incorporate product recovery in place, past cases can now be reexamined and the potential for generalizability of the approach to similar types of other problems and applications can be assessed and determined.
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