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Leiomyoma is the most common benign neoplasm of the uterus and gastrointestinal tract, but it is rare in the oral cavity. Also, its occurrence in the tongue is very rare because there is so little smooth muscle tissue present in this region. Clinically, oral leiomyoma usually grows slowly and is generally a non-ulcerated, small (1 to 2 cm), painless, sessile, firm and superficial nodule like lesion, although several authors have reported painful lesions. The diagnosis and treatment of oral leiomyoma is possible with complete surgical excision and histological studies by special stains. Recently, we experienced a 42-year-old woman with 6 month history of protruding tongue mass. She underwent surgical excision and the final pathological result confirmed it to be vascular leiomyoma. We report this case with a review of the related literatures.