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purpose. To determine, the effects of saline, heparin 2 units (U) per ml saline, and heparin 10 U/ml saline flush solutions on the duration of intravenous (IV) locks and the incidence of IV infiltration in neonates. design. Randomized double‐blind experiment. setting. Tertiary‐care nursery. participants. Neonates (N = 90) hospitalized at birth in the intensive, intermediate care, or newborn units. main outcome measures. Total hours from the time the IV was inserted to the time the IV was removed; hours from the time the IV was first flushed to the time the IV was removed; number of IVs removed because of infiltration. results. No statistical or clinical differences between the three groups for duration of IV nor for incidence of complications. conclusions. The use of heparin in IV lock flush solution did not affect the duration of IV locks nor the incidence of infiltration in neonates.

Albumin and betaa-microglobulin excretions were studied in 85 unselected patients treated with lithium for more than 6 months. In 15 patients a lithium-induced impaired renal concentrating ability was found, 13 of these patients revealed a chronic interstitial nephropathy on renal biopsy. There was no significant increase in albumin excretion, and a markedly increased beta₂-microglobulin excretion was seen in only 1 patient. This study supports the hypothesis that the lithium-induced renal lesion is confined to the distal part of the nephron.

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