The development of a stereoselective one-pot oxidative [3,3] sigmatropic rearrangement/Friedel-Crafts arylation that provides enantioenriched benzhydryl compounds is reported. The utility of this new transformation is demonstrated by the concise synthesis of several tetralone- and naphthyl-type lignan natural products, many of which display anti-malarial activity.

The development of a triflimide-catalyzed annulation of benzylic alcohols with allylsilanes for the divergent synthesis of indane or tetralin structures from common precursors is reported.

This review highlights strategies for the enantioselective total synthesis of cyclolignan natural products from 2000 to 2021. Each subsection focuses on the key strategic disconnections and the enantioselective steps controlling asymmetric induction.

The development of a stereoselective one-pot oxidative [3,3] sigmatropic rearrangement/Friedel-Crafts arylation that provides enantioenriched benzhydryl compounds is reported. The utility of this new transformation is demonstrated by the concise synthesis of several tetralone-and naphthyl-type lignan natural products, many of which display anti-malarial activity.

A stereoselective one‐pot oxidative [3,3] sigmatropic rearrangement/Friedel—Crafts arylation is developed to provide a convenient synthesis of benzhydryl compounds.