Objective. Reconstruction of the lower lip is complex. The Colmenero flap is an effective albeit rarely described method for the repair of medium-to large-sized defects of the lower lip. Methods. A retrospective review was carried out using data gathered from patients who had undergone Colmenero flap reconstruction of the lower lip at our centre between 2015 and 2020. We analysed demographic, histologic and anatomic variables as well as surgical results. This review assessed flap functionality based on proper mouth closure, absence of microstomia and oral competence. Results. Thirteen Colmenero flaps were performed in 9 patients, with the flap being used bilaterally in four cases. All patients had squamous cell carcinoma of the lower lip. The mean length of the reconstructed defect was 4.1 cm (ranging between 3-7.5 cm). None of the flaps exhibited signs of necrosis. Five patients required minor surgical touch up during the second procedure: two for dehiscence, two for oral leakage and one for esthetic improvement. All patients had excellent functional and aesthetic final outcomes. Conclusions. The Colmenero flap is a good resource for medium-and large-sized lower lip reconstructions due to its reliability, limited complications, and good aesthetic and functional results.