Nicotine addiction and dependence is a chronic relapsing disease driven by addiction to nicotine. Proactive treatment for all tobacco users, regardless of their readiness to quit, is recommended. First-line tobacco cessation medications include nicotine replacement therapy, bupropion, and varenicline. Comprehensive treatment with behavioral interventions and pharmacologic therapy increases success rates of smoking cessation. Although there are many popular alternative treatments, they should not replace or delay the use of known effective therapies. KEY POINTSAn individualized treatment for tobacco cessation is necessary and should be based on severity of nicotine dependence, probability of developing withdrawal symptoms, comorbidities, local resources, and patient preferences.Comprehensive smoking cessation treatment provides counseling, assesses the patient's readiness to quit, offers treatment options, and arranges follow-up.Evidence is lacking to support the use of smart phone "apps" for smoking cessation as monotherapy. E-cigarettes are not used in tobacco cessation treatment as they can also cause nicotine addiction and other concerns.

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