Common and rare arterial collateral pathways are reviewed by 3D volume-rendered CT images. Visceral and lower extremity arterial embryology is reviewed.
Twenty-two patients with malignant biliary obstruction and 21 patients with suspected obstruction of biliary-enteric anastomoses were evaluated over a 12-month period with magnetic resonance (MR) cholangiography and cross-sectional MR imaging. In patients with malignant obstruction, MR cholangiography helped accurately determine the status of the biliary ductal system by identifying the exact location and extent of the obstruction and the severity of duct dilatation. In so doing, MR cholangiography helped determine whether percutaneous transhepatic cholangiography with antegrade stent placement or retrograde cholangiography with stent placement constituted the more suitable treatment. Cross-sectional MR imaging was necessary to identify the organ of tumor origin, define the tumor margins, and determine the stage of disease. This information helped evaluate the appropriateness of curative surgical therapy versus palliative drainage procedures. In patients with biliary-enteric anastomoses, MR cholangiography clearly depicted the site of the anastomosis and demonstrated the status of the intrahepatic ducts, thereby helping determine which patients would benefit from undergoing antegrade duct cannulation with a drainage procedure or perhaps balloon dilation. In some of these patients, MR cholangiography was sufficient to help plan therapeutic intervention. MR cholangiography also demonstrates the presence and size of biliary stones and associated findings such as intraductal tumor growth. In addition, MR cholangiography may obviate retrograde cholangiography, which can be technically difficult to perform.
Despite the promising
results from the placement of covered or
uncovered self-expandable metallic stent (SEMS) as a nonsurgical therapeutic
option for the malignant gastric outlet obstruction (GOO), the long
patency of the stent is still limited because of stent-induced tissue
hyperplasia. Here, a local heat treatment using a nanofunctionalized
SEMS is proposed for suppressing stent-induced tissue hyperplasia
during GOO treatment. Highly efficient photothermal gold nanoparticle
(GNP) transducer-coated SEMSs (GNP-SEMSs) were prepared for local
heat treatment in rat gastric outlet. The in vivo heating temperature
in rat gastric outlet model was evaluated and compared with in vitro
heating temperature. Three groups of our developed 45 rat gastric
outlet models were used: group A, noncoated SEMS only; group B, GNP-SEMS
plus local heating; and group C, GNP-SEMS only to investigate in vivo
efficacy of GNP-SEMS mediated local heating. Ten rats per group were
sacrificed for 4 weeks, and five rats per group were sacrificed immediately
after local heat treatment. The in vivo heating temperature was found
to be 10.8% lower than the in vitro heating temperatures. GNP-SEMSs
were successfully placed through a percutaneous approach into the
rat gastric outlet (n = 45). The therapeutic effects
of GNP-SEMS were assessed by histologic examination including hematoxylin-eosin,
Masson trichrome, immunohistochemistry (TUNEL and CD31), and immunofluorescence
(Ki67), and the results showed significant prevention of tissue hyperplasia
following stent placement without adjacent gastrointestinal tissue
damage. GNP-SEMS-mediated local heating could be an alternative therapeutic
option for the suppression of tissue hyperplasia following stent placement
in benign and malignant GOOs.
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