Experimental data of excess enthalpy, (H E ), density, (ρ), speed of sound, (u), and the refractive index, (n D ), are reported in this work for ternary and binary mixtures composed of diethylene glycol monoethyl ether (2-(2-ethoxyethoxy)ethanol), heptane, and isooctane at 0.1 MPa and 298.15 and 313.15 K, over the whole set of mole fractions (680 points). Based on it, derivative properties such as excess volume, (V E ), isentropic compressibility, (κ s ), deviation in isentropic compressibility, (Δκ s ), and deviation in the refractive index, (Δn D ), were determined. The Redlich−Kister equation is used to correlate the excess enthalpies, excess volumes, deviations in isentropic compressibility, and deviations in the refractive index. Also, the predictive Peng−Robinson 1978 (PPR78) equation of state (EoS) is employed to model the experimental data of H E . To predict the H E data, the NRTL and UNIQUAC models are applied, relatively to the PPR78 EoS. In addition, the perturbed chain-statistical associating fluid (PC-SAFT) equation of state is employed to fit the density measured data for the ternary and binary mixtures. Intermolecular interactions have been discussed for the studied binary and ternary mixtures. No reference data were found in the literature for binary or ternary mixtures containing 2-(2-ethoxyethoxy)ethanol, with the purpose of making a comparison with our presented experimental data.