We believe that the ongoing global pandemic has highlighted the need for comprehensive approaches to address issues that transcend geographical and cultural boundaries. Therefore, this article aims to provide a general but abstract review to allow readers of a broad spectrum to learn the basic principles of three related concepts: systems, cybernetics, and complexity. Additionally, to better exemplify these concepts, we offer a review of works from the last decade that use systems theory, complexity, and cybernetics for their development. In this context, the result of this review will allow for breaking down the barriers of reductionist silos of knowledge and fostering a multidisciplinary and interdisciplinary dialogue.