Recently, it was demonstrated that doxorubicin (Dox.HCl), a chemotherapeutic agent, could be photoactivated by Cerenkov radiation (CR). The objective of the present work was to develop a multimodal chemotherapy-radiotherapy-photodynamic therapeutic system based on reconstituted high-density lipoprotein (rHDL) loaded with Dox.HCl and 177Lu-DOTA. 177Lu acts as a therapeutic radionuclide and CR source. The system can be visualized by nuclear imaging. Fluorescence microscopy showed that rHDL-Dox specifically recognized cancer cells (T47D) that are positive for SR-B1 receptors. Encapsulated Dox.HCl was released into the cells and produced reactive oxygen species when irradiated with a 450-nm laser (photodynamic effect). The same effect occurred when Dox.HCl was irradiated by 177Lu CR. Through in vitro experiments, it was confirmed that the addition of 177Lu-DOTA to the rHDL-Dox nanosystem did not affect the specific recognition of SR-B1 receptors expressed in cells, or the cellular internalization of 177Lu-DOTA. The toxicity induced by the rHDL-Dox/177Lu nanosystem in cell lines with high (T47D and PC3), poor (H9C2) and almost-zero (human fibroblasts (FB)) expression of SR-B1 was evaluated in vitro and confirmed the synergy of the combined chemotherapy-radiotherapy-photodynamic therapeutic effect; this induced toxicity was proportional to the expression of the SR-B1 receptor on the surface of the cells used. The HDL-Dox/177Lu nanosystem experienced uptake by tumor cells and the liver-both tissues with high expression of SR-B1 receptors-but not by the heart. 177Lu CR offered the possibility of imparting photodynamic therapy where laser light could not reach.

Examinando el modelo de metas de logro 3x2 en el contexto de la Educación Física Examining the 3x2 Achievement Goal Model in the Physical Education context Examinando as metas de realização modelo 3x2, no contexto da Educação FísicaAntonio Méndez-Giménez, José-Antonio Cecchini-Estrada y Javier Fernández-Río Universidad de Oviedo. Facultad de Formación del Profesorado y EducaciónResumen: Esta investigación examina el modelo de metas de logro 3x2 (Elliot, Murayama y Pekrum, 2011) en el contexto de la Educación Física. Este modelo se fundamenta en las dimensiones de nición y valencia de la competencia, y se compone de seis constructos de meta. En el estudio 1, se elaboró un instrumento especí co, el Cuestionario de Metas de Logro 3x2 en Educación Física (CML 3x2-EF), y fue completado por una muestra de 150 estudiantes (75 varones y 75 mujeres) con una edad media de 13.97 años (DT = 1.23). Los resultados del Análisis Factorial Con rmatorio apoyaron con rmeza el modelo hipotético. La validez y consistencia interna fueron satisfactorias. El modelo hipotético, comparado con otros 10 modelos alternativos, produjo el mejor ajuste a los datos. En el estudio 2 (N= 366) se reexaminó el modelo y se realizaron análisis de regresión para explorar las metas de logro como predictoras de variables dependientes: motivación autodeterminada, competencia percibida, autoconcepto (subescalas habilidad, atractivo físico y condición física), metas de amistad (aproximación y evitación). Los datos se ajustaron a las predicciones y produjeron evidencias de patrones predictivos diferenciales entre las metas basadas en la tarea y las metas basadas en el yo. Palabras claves: Motivación; Metas; Competencia; De nición; Valencia Abstract: is research examines the 3x2 achievement goals model (Elliot, Murayama, and Pekrum, 2011) in the physical education context. is model is based on two dimensions of competence: de nition and valence, and it includes six goal constructs. In Study 1, a speci c instrument was developed, the 3x2 Achievement Goals Questionnaire in Physical Education (3x2 AGQ-PE). It was completed by a sample of 150 students (75 males and 75 females) with a mean age of 13.97 years (SD = 1.23). Con rmatory factor analysis strongly supported the hypothesized model. Validity and internal consistency were satisfactory. e hypothetical model, compared with 10 alternative models produced the best t to the data. In Study 2 (N = 366) the model was re-examined and a series of regression analysis were performed to explore achievement goals as predictors of several dependent variables: selfdetermined motivation, perceived competence, self-concept (ability, physical attractiveness and physical condition), friendship goals (approach and avoidance). Data tted the predictions and produced evidence of di erential predictive patterns between task-based goals and self-based goals. Cuadernos de Psicología del Deporte, vol. 14, n.º 3 (octubre)

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