Objective
To assess the effect of the adherence to medical treatment on urinary parameters in the 24-h metabolic study of patients with kidney stones.
Methods
A retrospective, longitudinal, descriptive, and observational study was carried out by reviewing the hospital electronic medical record from 2014 to 2018. The adherence to drug treatment was measured 6 months after its initiation, and the numerical values of the metabolic studies were compared. Wilcoxon tests were performed to compare the difference before and after treatment.
Results
Ninety patients were evaluated, with 73.3% of adherence. The 180-day overall adherence rate was 61.2% in patients treated with a single drug and 85.4% in patients treated with multiple drugs. There is a statistically significant increase in citrate levels in patients with good adherence in comparison with non-adherent patients (
p
=0.031
vs.
p
=0.528).
Conclusions
Medical treatment and dietary measures in patients with kidney stones have an initial impact at 6 months on the values of the main urinary metabolic alterations that predispose to calculi formation; the most significant is seen in those patients with adherence to medical treatment for hypocitraturia.
ANTECEDENTES: La estenosis de la anastomosis vesicouretral es una complicación importante de la prostatectomía radical, a mediano y largo plazos, con incidencia y causalidad heterogénea. OBJETIVO: Analizar y determinar las causas relacionadas con la estenosis de la anastomosis vesicouretral, incluidas las características propias del paciente y los factores clínicos pre, trans y posoperatorios. MATERIALES Y MÉTODOS: Estudio de casos y controles, retrospectivo efectuado con base en la información de los expedientes de pacientes admitidos en el servicio de Urología del Hospital Juárez de México, entre los años 2010 a 2016, con diagnóstico de cáncer de próstata y prostatectomía radical extraperitoneal videoendoscópica. Para el análisis estadístico se calculó el riesgo relativo y se utilizaron las pruebas de c2 y t de Student. RESULTADOS: Se registraron 74 pacientes. En 31/74 se estableció el diagnóstico de estenosis durante el seguimiento mínimo de 3 años, quienes requirieron un nuevo tratamiento endoscópico o dilataciones. Factores de riesgo: diabetes mellitus (p = 0.003), técnica de sutura interrumpida de anastomosis (p = 0.03), volumen prostático menor (media de 53 g; p = 0.02) y radioterapia posoperatoria (p = 0.001). CONCLUSIONES: La incidencia de estenosis de la anastomosis vesicouretral es elevada. Los factores de riesgo asociados incluyen: diabetes mellitus, técnica de sutura interrumpida, radioterapia coadyuvante y volumen prostático menor (53 g). PALABRAS CLAVE: Estenosis de la anastomosis vesicouretral; prostatectomía radical; cáncer de próstata.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.