Introduction: Neoplasms are one of the leading causes of death worldwide, identifying trends in mortality is important for the establishment of prevention and diagnostic strategies in susceptible populations. Objective: To identify the main types of cancer in death women of reproductive ages in Chiapas, the socioeconomic factors, and mortality rates due to these causes. Materials and methods: Descriptive, retrospective cross-sectional, study, based on an analysis of national mortality databases. The universe corresponded to cancer deaths in Mexico during the period 2016-2020, the sample corresponded to cancer deaths in women in Chiapas aged 15 to 44 years in the same period. Results: 3.6% of deaths due to neoplasms in Mexico occurred in Chiapas (15,814). A total of 104 different types of cancer were registered in the state. The most frequent were malignant cervix tumors with 19.2% (n= 263), malignant breast tumor with 12.5% (n=171) and malignant stomach tumor with 9.1% (n=125). The specific mortality rate for cancer in the state in 2020 corresponded to 10.4 per 100,000 women. Conclusions: Cancer mortality at the state level has been maintained with minimal percentage differences each year (0.7%), but exceeds the projected at a national level. The most frequent types of cancer associated with deaths of women in Chiapas are cervical, breast, and stomach cancer.