Soil contamination by heavy metals is a problem that is increasing worldwide due to human activities, and it is important to bear in mind that its toxicity and abundance in ecosystems can be serious. The remediation of these contaminated environments should be a priority in all countries, since the consequences that have been recorded are harmful to human and environmental health. In humans, it causes different diseases and even metals bioaccumulate in the human body, as well as in plants and animals, which come as food to the tables of many homes. Therefore, the objective of this chapter is to show the implications and consequences that heavy metals cause. In addition, show evaluation methods and techniques, such as the ecological risk index, to generate data that help investigations and possible alternatives for sustainable remediation. The impact that this theme must be relevant in the penta helix; because all the actors (government, society, business, academia, and civil associations) must cooperate and get involved for inclusive sustainability that provides solutions for the recovery of contaminated ecosystems, as well as for the care of human and environmental health.