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Los efectos adversos que se presentan con más frecuencia por el empleo de estatinas son los musculoesqueléticos. Sus manifestaciones van desde el efecto nocebo, mialgias, debilidad, atrofia muscular, miositis, y, excepcionalmente, rabdomiólisis. Su patogenia es diversa, pero destacan la predisposición individual y la multimorbilidad. Existen estrategias para su tratamiento y prevención; para los casos de intolerancia verdadera o de efectos tóxicos graves, ya existen medicamentos alternativos y eficaces para disminuir el c-LDL. Las estatinas representan uno de los medicamentos más empleados en la terapéutica médica actual, por lo que es importante conocer y tener presente sus efectos adversos para su prevención, vigilancia, detección y tratamiento oportuno. Palabras clave: Miopatía por estatinas, toxicidad por estatinas, efectos adversos de hipolipemiantes, miopatía por fármacos, intolerancia a estatinas.

The global spread of SARS-CoV-2 has resulted in a public health crisis and major economic impact, with millions of confirmed cases and deaths worldwide. An important aspect of controlling the spread of the virus is testing individuals for COVID-19. Currently, the gold standard is the association of  RT-qPCR with the Nasopharyngeal Swab (Ns), which is uncomfortable and requires specialized personnel for sample collection. Mass testing, unprecedented in human history, leads to the search for innovations and facilities in the methodology, but which maintains diagnostic security, even in the face of new variants of the virus. This study aimed to evaluate a less invasive alternative method, collecting samples from the oral mucosa with a swab (Os). For comparison, the same patients were tested using biological material collected through Os and Ns. Samples were processed and analyzed by RTq-PCR. Results showed 100% concordance between Ns and Os samples from elderly patients, and SARS-CoV-2 was detected in saliva samples up to 14 days after the onset of symptoms in 31.25% of hospitalized patients. Our data and conclusion provide an important base for future studies of standardization and validation of the procedure described here. Using a more comfortable method could increase population adherence to testing and contribute to controlling the transmission of COVID-19.

The COVID-19 pandemic has led to a health system crisis, deaths and socioeconomic hardship. In order to minimize the consequences of the COVID-19 pandemic in the municipality of Lavras, a partnership was developed between the Lavras City Hall and the Universidade Federal de Lavras (UFLA). The present study aimed to describe the main prevention measures proposed in Lavras and to evaluate the community's perception of the management model towards COVID-19. A public online questionnaire, with 20 multiple-choice questions, about the measures to confront covid was submitted to the Google Forms platform from April 22nd to April 30th, 2020. The data regarding the strategies carried out to deal with COVID-19 was obtained from the published municipal ordinances. During the eight days that the questionnaire was applied, a total of 8,874 respondents from Lavras were obtained. Among these respondents, 31.64% (2,808) were men, 68.15% (6,047) were women, and 0.21% (19) declared "another option". When the participants were asked whether they are respecting the social distance measures, 7,452 (84.1%) of them answered "yes."Also, a total of 57.4% of the participants reported that the social distancing measures compromised their family income. However, despite the impact of this economic compromise on these families, 93.82% of the respondents believe that the measures applied are important. When analyzing the questionnaire responses, it was noticeable that despite residents suffering negative economic consequences, there was great popular approval of preventive measures, such as social distancing and the use of masks. In addition, it was possible to notice the population's trust in the measures recommended by professionals at UFLA and the city hall, highlighting the importance of establishing contact between authorities and the population during decision making.