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An Asymmetric Domino Three-Component Synthesis of β-Lactams.-Treatment of dialkyl cuprates either in a domino three-component or a sequential one-pot fashion with chiral Michael acceptors and the imine (III) bearing an electron-withdrawing C-substituent efficiently yields cis-α-alkyl-βlactams. The reaction with imines bearing electron-withdrawing N-substituents leads to trans-α-alkyl-β-lactams.With unactivated imines, no β-lactam formation is observed. -(PALOMO, C.; AIZPURUA, J. M.; GRACENEA, J. J.; GARCIA-GRANDA, S.; PERTIERRA, P.; Eur.

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