In the last decade one of the main opportunity areas of the cooler systems is increase their efficiency; for this, it has been innovating in materials and working fluids mainly. In the last decade one of the main areas of opportunity in refrigeration systems is the reference to increase their efficiency. For this, it has been innovating in materials and fluids of work mainly. In this work, the analysis of the transfer of calories in liquid cooling systems is analyzed by adding nanoparticles. These systems have different industrial and refrigeration applications in electronic systems. In the present work a configuration of the refrigeration system to be used is proposed. The analysis consists of the mathematical mode from the design of the geometry and the trajectory of the flow in the pipeline, in addition to a simulation in Computational Fluid Dynamics (CFD) of the system. The conditions are presented in the results.