Given that in Colombia the development of unconventional reservoirs is on its very preliminary phase, there are no studies related to the flowback treatment, which is a sensitive issue in making decisions to develop this energy resource in the country. Hence, this research proposes a methodology for selecting technically technologies suitable for flowback treatment in unconventional reservoirs in Colombia. A review of technical parameters and experiences in a real scale of different technologies, a sensitivity analysis of four water stability indexes, a correlation between flowback physical chemical parameters of a geological formation similar to Colombian geological formation and an economic analysis are presented. The best option always arises from the higher operational efficiency at the lowest cost.