RESUMO: "Levantamento das plantas medicinais usadas na região Nordeste do Brasil". Este trabalho teve como objetivo um levantamento das plantas e dos seus usos como medicinais, as quais são utilizadas com fi ns terapêuticos na região Nordeste do Brasil. A área de estudo é reconhecida por uma rica biodiversidade, principalmente de plantas e de hábitats, abrangendo desde a Floresta Amazônica, Floresta Atlântica, sistemas de mangues e dunas costeiras, até fl orestas secas e savanas. Como resultados, foram registrados um total de 650 espécies pertencentes a 407 gêneros e 111 famílias, e suas informações etnomedicinais. A diversidade fl orística é dominada por vegetais superiores e apenas cinco espécies das famílias Aspleniaceae, Cyatheaceae, Equisetaceae, Polypodiaceae e Selaginellaceae pertencem ao grupo das Pteridófi tas, que corresconde a menos que 1% do total das espécies registradas. Este estudo sugere a grande importância da investigação das espécies farmacologicamente ainda não estudadas, uma vez que seus usos populares estão registrados.
This review provides readers with an overview of the main synthetic methodologies for 1,3,4-oxadiazole derivatives, and of their broad spectrum of pharmacological activities as reported over the past twelve years.
Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
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