Sepsis is an organ dysfunction secondary to an infection, in which the patient develops an unregulated response to this aggression. It is considered one of the leading causes of mortality in critically ill patients, being related to high prevalence and mortality rates worldwide. Based on this explanation, this paper presents a literature review, highlighting the epidemiology and pathophysiology of sepsis. This article is an narrative review, covering scientific articles, monographs, theses and dissertations published in the databases: CAPES, SciELO and Google Scholar. Studies show that sepsis is a serious public health problem in the Intensive Care Unit (ICU), which despite a huge research effort in recent decades remains a considerable and growing challenge to health care. Finally, it is concluded that the main objective of the study can be achieved, and being a pathology with critical, acute and high prevalence, it is necessary to know about its causes, epidemiology and pathophysiological processes.

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Diabetes Mellitus is an important health problem that affects millions of people in Brazil and worldwide. The type Diabetes Mellitus 1 is a predominantly autoimmune pathology, where pancreatic ß cells are progressively destroyed, resulting in absolute insulin deficiency. This study aims to quantitatively describe the pharmacoepidemiological profile of patients with DM1 treated by the specialized pharmaceutical assistance component (CEAF) in Piauí. The research was carried out at CEAF / SESAPI, through a data survey carried out through analysis of protocols and records of patients with DM1 attended at this location from January to July 2017. The present study showed the patients with DM1 attended by CEAF / SESAPI, are predominantly teenagers and young adults, from the state capital. The survey showed that only 37% of DM1 patients have good glycemic control, showing a warning sign. It was shown that among the acute complications caused by DM1, hypoglycemia was the most frequent, in relation to chronic complications, 28% already had the same, with microalbuminuria being the most frequent. The prescriptions contained in the patients' protocols were analyzed and it was found that 42% of them were outside the requirements of the law, which can hinder the development of pharmacological therapy. Thus, it is possible to observe the importance of analyzing the pharmacoepidemiological profile of patients with DM1, as a relevant data for the discussion on the use of medications for DM1 patients of the CEAF / SESAPI specific to diabetics.

Esta pesquisa objetivou realizar identificação de S. aureus em carne bovina moída comercializada em municípios do Vale do Guaribas, no estado do Piauí. Coletou-se 50 amostras de carne bovina moída, adquiridas nos mercados e açougues públicos nos municípios pesquisados. Pesou-se 25g de cada amostra e transferiu-se cada amostra para Água Peptonada Tamponada 0,1%, onde realizou-se homogeneização e identificação das amostras e levou-se para estufa à 37 °C por 24 horas. Realizou-se o inóculo das amostras em placas de Petri contendo Ágar Baird-Parker (BP) e a incubação destas na estufa (em posição invertida) por 48 horas à 37°C. Inoculou-se as colônias típicas de S. aureus em tubos de ensaio contendo Caldo Infusão Cérebro Coração (BHI) e incubou-se à 37°C por 24 horas. Por fim, semeou-se, em placas de Petri contendo Ágar Sal Manitol, as amostras que apresentaram-se turvas no caldo BHI e incubou-se durante mesma temperatura e tempo. Para a identificação de Staphylococcus aureus, utilizou-se as colônias suspeitas, e realizou-se as seguintes provas bioquímicas: Coloração de Gram, prova da catalase e prova da coagulase. Após a execução da metodologia, verificou-se que das 50 amostras analisadas 32 (64%) apontaram resultado positivo para culturas de S. aureus após indicarem suspeitas de presença de colônias no ágar manitol. O alto número de amostras contaminadas pode ser explicado por diversos fatores que envolvem toda sua cadeia produtiva até o momento da comercialização das mesmas, promovendo cada vez mais aumento de casos de intoxicação alimentar pelas toxinas formadas nos alimentos em decorrência da presença deste patógeno.

The genus Salmonella spp. It belongs to the Enterobacteriaceae family and are bacteria that have a worldwide distribution, being present, especially, in animal production environments. About 1.9% of the cases of foodborne diseases caused by Salmonella are transmitted by pork meat and its derivatives, according to data from the Ministry of Health. In view of the above, this article aimed to investigate Salmonella in swine animals from growing meat trade and concern for public health. This study is an integrative review, covering scientific articles, monographs, theses and dissertations published in the databases: CAPES, SciELO and Google Scholar. Through studies, it is found that Salmonella spp. It is one of the main agents involved in foodborne diseases and pigs are considered important vehicles of these bacteria, acting as a source of infection, directly or indirectly, to humans. Finally, it can be concluded that the main objective of the study can be achieved, emphasizing the importance of reporting the cases of Salmonella contamination to the control departments, in order to direct the sanitary hygienic control measures, in order to ensure the safety of food of porcine origin and its derivatives, and the health of consumers.