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Our aim was to verify the modulative TP-4-ol capacity in 4-nitroquinoline-1-oxide induced oral rat cancer. Methods: The stereoisomers of TP-4-ol were used against the human tongue squamous cell line and the negative stereoisomer showed lower IC50. 31 Holtzman rats (120-130 grams) were cancer induced by 4-nitroquinoline-1-oxide (4-NQO/8 weeks/25 ppm) and 32 Holtzman rats (120-130 grams) were used to Healthy and TP-4-ol toxicity experiments. Six groups were used, healthy, 0.1nL/g of TP-4-ol, 8nL/g of TP-4-ol, 4-NQO, 4-NQO+0.1nL/g of TP-4-ol and 4-NQO+8nL/g of TP-4-ol. We performed the toxicity analysis by biochemical and histopathological analysis. The biochemistry analysis includes alkaline phosphatase [ALP], alanine aminotransferase [ALT], aspartate transaminase [AST], Urea and Creatinine and the histopathology analysis includes the liver, kidney, lung, and spleen. Specifically, for malign modulation we performed a macroscopic and microscopic analysis. Results: The group exposed to 0.1nL/g of TP-4-ol demonstrated a reduced risk of malignancy in dysplasia considering the criteria of architecture and cytology. Similarly, a drop of percentual rats with SCC diagnosis was observed in 4-NQO+0.1nL/g (41.6%) when compared to 4-NQO (87.5%). Moreover, the 4-NQO group presented a median of 2.62 SCC/rat and the 4-NQO+0.1nL/g demonstrated a median of 0.75 SCC/rat. For toxicity analysis, 4-NQO+0.1nL/g showed focal necrosis in the kidney and 4-NQO showed lung hemorrhagic areas. Conclusion: The concentration of 0.1nL/g was more effective in reducing the tongue induction of potentially malignant and malignant lesions by 4-NQO. A kidney toxicity was observed in healthy animals exposed to 0.1nL/g of TP-4-ol. Clinical relevance:The negative isoform of Terpinen-4-ol negatively modulates the development of potentially malignant and malignant lesions in rats (Rattus nonverdicts albinos, Holtzman) exposed to 4-NQO. (-)-Terpinen-4-ol reduced the mice percentual with squamous cell carcinoma, 87.5% to 41.6% and decreased the cancer/rat ratio of 2.62 in 4-NQO to 0.75 in 4-NQO+0.1nL/g. This represents 52.4% by group and 71.3% in the cancer/rat ratio.

Introduction: The Kissing Molar (KM) is defined by two or more lower posterior teeth in contact with the occlusal surfaces and the roots in opposite directions. Purpose: This study aimed to review epidemiological, clinical, and imaging aspects related to Kissing Molars. Methods: A two-phase systematic review registered in the PROSPERO platform was performed. Search strategies were developed for specific databases (PubMed, Scopus, Web of Science, Scielo, and LILACS), including the gray literature (Open Grey and Google Scholar). The CARE guideline was followed to evaluate methodological aspects, and the Joanna Briggs Institute instrument (MAStARI) assessed the risk of bias. Statistical analysis considered a 5% level of significance. Results: The initial search strategy resulted in 564 articles. From this total, 21 studies (case reports and case series) meet the eligibility criteria. The main aspects associated with KMs (n=32) were laterality difference between males and females (p=0.028), report of mental retardation (p=0.023), the involvement of second (p=0.036) and third (p<0.001) molars, surgical intervention (p<0.001) associating ostectomy and odontossection (p=0.028), and low occurrence of postoperative complications (p=0.002). Conclusion: A low number of KMs were reported in the literature. They showed statistically significant differences regarding epidemiological, clinical, imaging, and therapeutic characteristics. Thus, dental surgeons would consider these aspects before the treatment of patients with KMs.

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