PURPOSE: To study the effect of 1,8 cineoleee components of the essencial oil of Croton nepetaefolius - plant of North-East of Brasil, used in the popular medicine for riots of the gastrointestinal tract - on the motor behavior of the gut of Wistar rats. METHODS: Used 16 male animals under jejun of 24h weighing 300-350g. The effect of 1.8 cineoleee (1 or 3mg/Kg) on gastric compliance had been lead in anaesthetized rats. The variations of the gastric volume (GV), had been measured by plethysmography, while AP, HR and CVP had been monitored continuously by a digital system of data acquisition. RESULTS: Observe reduction of the GV, which was significant on 30, 40, 50 and 60min after treatment (2.0±0.1; 1.9±0.1; 1.8±0.1 and 1.7±0.1mL, versus 2.1±0.2mL). The AP presented significant fall after the administration of 1.8 cineoleee, remaining thus during 60min of monitorization (87.9±7.7; 87.6±7.1; 87.9±6.4; 87.8±5.7; 86.0±5.5 and 87.7±6.0mmHg, respectively versus 94.4±6.2 mmHg), as well as the HR (366.3±13.4; 361.7±11.5; 357.3±10.4; 353.0±10.4; 348.3±11.1 and 350.4±13.7bpm, respectively versus 395.2±11.1bpm). The CVP did not suffer significant variations after treatment. CONCLUSION: Observe the 1.8 cineoleee reduces the gastric compliance in anaesthetized rats besides presenting effect hipotensor and bradicardic; probably for direct action on the gastrointestinal and vascular smooth muscel and moduling the autonomic nervous system.

Introduction: The esophagus is subject to frequent reflux of gastric contents as a normal phenomenon during episodes of transient lower esophageal sphincter relaxation (tLESR), responsible too, for pathologic reflux. However, pathologic reflux is mostly associated with reflux of acid contents. Distending the stomach provokes an increase in frequency of tLESR. Objective: To investigate the effect of distending the rectum on the tLESR and possible involved pathways. Methods: Forty four (Protocol: 096/07) street dogs were selected and divided into respective protocols: Rectal distention (RD), Gastric distention (GD), RD+GD, Atropine+RD, Hexamethonium+RD, Baclofen+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD. We determined and compared the tLESR of each group and subjected data to statistical analysis. Values of p<0.05 were regarded as statistically significant. Results: RD provoked a significant increase in the tLESR just as GD, with RD+GD provoking the highest value of tLESR. This increase in tLESR due to RD was prevented in A+RD, B+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD but not Hexamethonium+RD protocols. Conclusion: RD is a significant inducer of an increase in tLESR with participation of muscharinic and GABAβ, sensitive and spinal cord neurons, but not nicotinic receptors.

INTRODUÇÃO: A CA é uma entidade clínica causada por infecção bacteriana do sistema biliar, mais comumente secundária à obstrução parcial ou completa do ducto biliar ou dutos hepáticos. OBJETIVO: descrever como é realizada nos dias atuais, o diagnostico e o tratamento da Colangite. METODOLOGIA: foi utilizado para a pesquisa as seguintes bibliotecas virtuais: a Biblioteca Virtual em Saúde (BVS), através da base de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs); a Scientific Eletronic Library Online (ScIELO) e o PubMed. A busca ocorreu no mês de setembro de 2020, utilizando os seguintes Descritores em Ciências da Saúde (DeCS): Colangite aguda, Colangite ascendente, Infecção biliar, Infecção do ducto biliar. RESULTADOS: A obstrução biliar é mais comumente causada por coledocolitíase, são encontrados em 10% a 15% da população branca nos Estados Unidos. É muito mais prevalente em nativos americanos (60%-70%) e hispânicos, mas menos comum em asiáticos e afro-americanos. Muitos pacientes são admitidos no hospital com cálculos biliares e 6% a 9% deles são diagnosticados com CA. Homens e mulheres são igualmente afetados. DISCUSSÃO: O início da colangite aguda envolve dois fatores: (i) aumento de bactérias no ducto biliar e (ii) pressão intraductal elevada no ducto biliar que permite a translocação de bactérias ou endotoxinas para o sistema vascular (refluxo colangiovenoso). A etiologia e a patogênese de várias formas de colangite são heterogêneas. A colangite pode ser desencadeada por mediadores genéticos e adquiridos. A avaliação por imagem do sistema hepatobiliar tem papel fundamental nas modalidades diagnósticas da colangite. O tratamento é direcionado aos dois principais componentes fisiopatológicos da colangite aguda, ou seja, infecção biliar e obstrução; portanto, tanto o tratamento sistêmico com antibióticos quanto a drenagem biliar continuam sendo as opções de tratamento básicas. CONCLUSÃO: O reconhecimento clínico imediato e o trabalho diagnóstico preciso, incluindo avaliação laboratorial adequada e imagens, são etapas críticas no tratamento da colangite. As variações no tratamento e nos fatores de risco que influenciam as taxas de mortalidade indicam a necessidade de critérios padronizados de diagnóstico, tratamento e avaliação da gravidade de forma imediata.

The ventriculoperitoneal shunt (VPS) is a solution to relieving symptoms of excess cerebral-ventricle cerebrospinal fluid (CSF); draining this extra fluid to the peritoneum. Other forms of shunts exist though less used in relation to VPS; whose choice is mainly determined by patient’s clinical presentation and regressive history. Though rare, VPS is not devoid of complications. Furthermore, primary abdominal complications are rarer, though most present as peritonitis, abscess or shunt catheter dissociation, each with varying short and long term consequences. Recently, abdominal fluid collections are drawing increasing interest, particularly in relation to: encysted collections (abdominal pseudocysts-APC) and excess cerebrospinal fluid (CSF) accumulation (called CSF ascites). We present a case of an abdominal APC diagnosed in an outpatient treated at our referral centre, and explore the involved clinical and surgical aspects. This patient was successfully treated and evolved well post-operatively and up-to-date. Despite vast evolution in neurosurgery, VPS continues being the prima choice in treating hydrocephalus, a procedure prone to complications just like any surgery, though rare. Non-draining shunts usually warrant revision which usually means at least a reoperation. Mechanisms leading to APC formation remain unknown, although a previous bout of sub-clinical peritonitis continues being the dominant hypothesis.