The fruits of Sapindus Saponaria L., popularly known as "saboeiro", have been used in medicine. This study evaluated the antioxidant and antitumor activities of the hydroethanolic extract (HAE) and fractions obtained from the fruit pericarp of S. saponaria. The HAE was obtained from the S. saponaria fruit pericarp by maceration; this was followed by fractionation using reversed-phase solid-phase extraction, resulting in fractions enriched with acyclic sesquiterpenic oligoglycosides (ASOG) and saponins (SAP1, and SAP2), confirmed by mass spectrometry with electrospray ionization (ESI-QTOF-MS). The greatest antiproliferative activity was observed with the SAP1 fraction against the CaCo2 cell line with a GI50 of 8.0 µg mL -1 , while the SAP2 fraction had a GI50 of 13.6 µg mL -1 against CaCo2. The ASOG and SAPs fractions demonstrated the greatest antioxidant activity. S. saponaria has potential therapeutic use in the pharmaceutical industry as a natural anti-oxidant or antitumor product.

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