Spatial climate data sets of 1971-2000 mean monthly precipitation and minimum and maximum temperature were developed for the conterminous United States. These 30-arcsec (∼800-m) grids are the official spatial climate data sets of the U.S. Department of Agriculture. The PRISM (Parameter-elevation Relationships on Independent Slopes Model) interpolation method was used to develop data sets that reflected, as closely as possible, the current state of knowledge of spatial climate patterns in the United States. PRISM calculates a climate-elevation regression for each digital elevation model (DEM) grid cell, and stations entering the regression are assigned weights based primarily on the physiographic similarity of the station to the grid cell. Factors considered are location, elevation, coastal proximity, topographic facet orientation, vertical atmospheric layer, topographic position, and orographic effectiveness of the terrain. Surface stations used in the analysis numbered nearly 13 000 for precipitation and 10 000 for temperature. Station data were spatially quality controlled, and short-period-of-record averages adjusted to better reflect the 1971-2000 period.PRISM interpolation uncertainties were estimated with cross-validation (C-V) mean absolute error (MAE) and the 70% prediction interval of the climate-elevation regression function. The two measures were not well correlated at the point level, but were similar when averaged over large regions. The PRISM data set was compared with the WorldClim and Daymet spatial climate data sets. The comparison demonstrated that using a relatively dense station data set and the physiographically sensitive PRISM interpolation process resulted in substantially improved climate grids over those of WorldClim and Daymet. The improvement varied, however, depending on the complexity of the region. Mountainous and coastal areas of the western United States, characterized by sparse data coverage, large elevation gradients, rain shadows, inversions, cold air drainage, and coastal effects, showed the greatest improvement. The PRISM data set benefited from a peer review procedure that incorporated local knowledge and data into the development process.

A prospective, randomized, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin (loading dose of 33 mg/kg, 16 mg/kg every 6 h for 4 days, and 8 mg/kg every 8 h for 3 days) was conducted in 242 patients with serologically confirmed hemorrhagic fever with renal syndrome (HFRS) in the People's Republic of China. Mortality was significantly reduced (sevenfold decrease in risk) among ribavirin-treated patients, when comparisons were adjusted for baseline risk estimators of mortality (P = .01; two-tailed). HFRS typically consists of five consecutive but frequently overlapping clinical phases. Only occurrence of oliguric phase and hemorrhage was associated with severity of clinical disease in the placebo group. Ribavirin therapy also resulted in a significant reduction in the risk of entering the oliguric phase and experiencing hemorrhage. The only ribavirin-related side effect was a well-recognized, fully reversible anemia after completion of therapy.

Spatial climate datasets of 1981–2010 long-term mean monthly average dew point and minimum and maximum vapor pressure deficit were developed for the conterminous United States at 30-arcsec (~800m) resolution. Interpolation of long-term averages (twelve monthly values per variable) was performed using PRISM (Parameter-elevation Relationships on Independent Slopes Model). Surface stations available for analysis numbered only 4,000 for dew point and 3,500 for vapor pressure deficit, compared to 16,000 for previously-developed grids of 1981–2010 long-term mean monthly minimum and maximum temperature. Therefore, a form of Climatologically-Aided Interpolation (CAI) was used, in which the 1981–2010 temperature grids were used as predictor grids. For each grid cell, PRISM calculated a local regression function between the interpolated climate variable and the predictor grid. Nearby stations entering the regression were assigned weights based on the physiographic similarity of the station to the grid cell that included the effects of distance, elevation, coastal proximity, vertical atmospheric layer, and topographic position. Interpolation uncertainties were estimated using cross-validation exercises. Given that CAI interpolation was used, a new method was developed to allow uncertainties in predictor grids to be accounted for in estimating the total interpolation error. Local land use/land cover properties had noticeable effects on the spatial patterns of atmospheric moisture content and deficit. An example of this was relatively high dew points and low vapor pressure deficits at stations located in or near irrigated fields. The new grids, in combination with existing temperature grids, enable the user to derive a full suite of atmospheric moisture variables, such as minimum and maximum relative humidity, vapor pressure, and dew point depression, with accompanying assumptions. All of these grids are available online at http://prism.oregonstate.edu, and include 800-m and 4-km resolution data, images, metadata, pedigree information, and station inventory files.

High-quality, daily meteorological data at high spatial resolution are essential for a variety of hydrologic and ecological modeling applications that support environmental risk assessments and decision making. This paper describes the development, application, and assessment of methods to construct daily highresolution (ϳ50-m cell size) meteorological grids for the 2003 calendar year in the Upper South Santiam Watershed (USSW), a 500-km 2 mountainous catchment draining the western slope of the Oregon Cascade Mountains. Elevations within the USSW ranged from 194 to 1650 m. Meteorological elements modeled were minimum and maximum temperature; total precipitation, rainfall, and snowfall; and solar radiation and radiation-adjusted maximum temperature. The Parameter-Elevation Regressions on Independent Slopes Model (PRISM) was used to interpolate minimum and maximum temperature and precipitation. The separation of precipitation into rainfall and snowfall components used a temperature-based regression function. Solar radiation was simulated with the Image-Processing Workbench. Radiation-based adjustments to maximum temperature employed equations developed from data in the nearby H. J. Andrews Experimental Forest. The restrictive terrain of the USSW promoted cold-air drainage and temperature inversions by reducing large-scale airflow. Inversions were prominent nearly all year for minimum temperature and were noticeable even for maximum temperature during the autumn and winter. Precipitation generally increased with elevation over the USSW. In 2003, precipitation was nearly always in the form of rain at the lowest elevations but was about 50% snow at the highest elevations. Solar radiation followed a complex pattern related to terrain slope, aspect, and position relative to other terrain features. Clear, sunny days with a large proportion of direct radiation exhibited the greatest contrast in radiation totals, whereas cloudy days with primarily diffuse radiation showed little contrast. Radiation-adjusted maximum temperatures showed similar patterns. The lack of a high-quality observed dataset was a major issue in the interpolation of precipitation and solar radiation. However, observed data available for the USSW were superior to those available for most mountainous regions in the western United States. In this sense, the methods and results presented here can inform others performing similar studies in other mountainous regions.

In many regions of the world, the extremes of winter cold are a major determinant of the geographic distribution of perennial plant species and of their successful cultivation. In the United States, the U.S. Department of Agriculture (USDA) Plant Hardiness Zone Map (PHZM) is the primary reference for defining geospatial patterns of extreme winter cold for the horticulture and nursery industries, home gardeners, agrometeorologists, and plant scientists. This paper describes the approaches followed for updating the USDA PHZM, the last version of which was published in 1990. The new PHZM depicts 1976-2005 mean annual extreme minimum temperature, in 2.88C (58F) half zones, for the conterminous United States, Alaska, Hawaii, and Puerto Rico. Station data were interpolated to a grid with the Parameter-Elevation Regressions on Independent Slopes Model (PRISM) climate-mapping system. PRISM accounts for the effects of elevation, terrain-induced airmass blockage, coastal effects, temperature inversions, and cold-air pooling on extreme minimum temperature patterns. Climatologically aided interpolation was applied, based on the 1971-2000 mean minimum temperature of the coldest month as the predictor grid. Evaluation of a standard-deviation map and two 15-yr maps (1976-90 and 1991-2005 averaging periods) revealed substantial vertical and horizontal gradients in trend and variability, especially in complex terrain. The new PHZM is generally warmer by one 2.88C (58F) half zone than the previous PHZM throughout much of the United States, as a result of a more recent averaging period. Nonetheless, a more sophisticated interpolation technique, greater physiographic detail, and more comprehensive station data were the main causes of zonal changes in complex terrain, especially in the western United States. The updated PHZM can be accessed online (http://www.planthardiness.ars.usda.gov).