The purpose of the study was to find out the key constructs of e-learning towards customer satisfaction of distance learning students in Ghana. Four hypotheses were formulated for the study. A cross-sectional survey design that adopted the quantitative research approach was used. A sample size of 420 was selected using convenient sampling. Data was analysed with SPSS. Spearman’s correlation and multiple regression analysis were used to analyze the hypotheses. The study revealed that course flexibility and learners’ interaction with others were the major factors that positively impacted customer satisfaction. Therefore, the study recommended that time schedules for online courses should be “rigid free” and not subjected to strict times which are unpleasant for learning and discussions. The study concluded that to continue enabling marginalized and disadvantaged students to access distance-learning education, policymakers need to hear the voices of distance-learning students on course flexibility and learners’ interactions. Keywords: E-learning, Customer Satisfaction, Distance Education Students, Course Construct.