The Himalayas are a repository of tremendous wealth of medicinal plants. Kumaun and Garhwal are characterized by a rich diversity of ethno-medicinal plants as well as a rich heritage site in traditional medicine system in the western Himalayan region. Present study deals with the status, identification and to explore the traditional knowledge of plant Premna Barbata Wall. Ex Schauer about its uses in local medicine by village people in Kumaun, Garhwal region in India and other western Himalayan Countries. The genus Premna contains 200 species under the family Verbenaceae all over the world and out of that approximately 30 species are present in India and are native mainly to the tropical and subtropical Asia, Africa, Australia and the Pacific islands. Premna Barbata Wall. Ex Schauer plant is belonging to family Verbenaceae. It is distributed in the forest area of the Eastern and northern parts of India, Pakistan, Nepal, and Myanmar and nearby regions.The present paper is a review on ethno-medicinal uses of Premna Barbata Wall. Ex Schauer, which is widely used by different tribes and medicinal practitioners for treatment of various diseases. Different parts of the plant (bark, wood and leaves) are variably used in treating wide range of diseases such as joints and back pain, dropsy, ulcer, diarrhea, wound healing, throat infection, antibacterial, fever, herpes complex disease, arthritic pain. With this review it is concluded that there is a need for conducting further investigation and studies for pharmacognostic characteristics and the isolation of individual active constituents form Premna Barbata Wall. Ex Schauer plant. Also the study is expected to provide basic data for further studies aimed at conservation of traditional medicine.

Background: Polycystic ovary syndrome is the commonest endocrinopathy in anovulatory infertility in young women. It is estimated that infertility affects 10 to 14% of the Indian population of which approximately 25-30% part occupied by PCOS. Methods: This prospective study enrolled 180 infertile women with PCOS, age 21-35 yrs who have taken 1 cycle of clomiphene citrate 100 mg, endometrial thickness <7 mm inspite of follicles greater than 18 mm. Half of them treated with clomiphene citrate with estradiol valerate and remaining half with letrozole. Results: In Group-A treated with clomiphene citrate with estradiol valerate 13 patients (16.3%) conceived and in Group-B treated with letrozole 26 patients (32.5%) conceived. Conclusion: Pregnancy rate is higher in group which treatment with letrozole in comparison with clomiphene citrate plus estradiol valerate. Keywords: Polycystic ovary syndrome, Infertility, Pregnancy rate