Climate changes are rapidly intensifying and can lead to adverse global health impacts. Indigenous populations are especially vulnerable to climate change because of their dependence on the environment for cultural activities and subsistence. The voices of Inuit Elders and seniors encompass deep wisdom and history; as such, the goal of this research was to examine the perceived impacts of climate and environmental changes on physical, mental, and emotional health, as observed by Elders and seniors in the Inuit community of Rigolet, Nunatsiavut, Labrador, Canada. A mixed-methods approach was used to gather data capturing these local observations, as well as perceived impacts on community health. A community survey was administered in November 2009 (n = 75) and in-depth interviews were conducted with Elders and seniors from January to October 2010 (n = 22). Survey results indicated that Elders and seniors observing changes in weather patterns, water systems, and wildlife were more likely to perceive climate change impacts on health (p < 0.05). Emergent themes from the interviews included: recurring observations of climate change, including changes in temperature, ice, snow, and seasonal timing; impacts on physical health, including reduced 6 ᐅᖃᓕᒫᒐᖅ ᓄᓇᖃᖅᑳᖅᓯᒪᔪᓄᑦ ᐋᓐᓂᐊᖅᑐᓕᕆᓂᕐᒥᑦ, ᐊᐅᔭᖅ 2015