Daño cardiaco frente a hepático por consumo de bebidas energizantes en ratas cepa HoltzmanRESUMEN Objetivo: El consumo de bebidas energéticas (BE) está aumentando principalmente en jóvenes, debido a que promete mejorar el estado de alerta, el rendimiento físico y cognitivo y evita la fatiga. En nuestro país, una BE tiene alta concentración de cafeína y azúcar por botella, y es altamente comercializada y barata. Sin embargo, las BE tienen efectos adversos como complicaciones cardiovasculares, neurales y gastrointestinales. Los estudios indican un mayor daño en hígado y corazón, señalados por altos niveles séricos de GOT y daño tisular. El objetivo de nuestro estudio es determinar si el corazón o hígado, presenta más daño por consumo de BE en ratas Holtzman. Métodos: Se clasificaron 32 ratas Holtzman macho aleatoriamente en dos grupos con tratamientos diferentes por administración oral. El Grupo 1 (Control) recibió agua potable y el Grupo 2 (Experimental) recibió una bebida energética de 5,49 ml / 260 g; ambos grupos durante 30 días. Se proporcionó aclimatación previa y alimento. Durante el período experimental, hubo cuatro extracciones de sangre para análisis de GOT sérico. Se sacrificaron por exanguinación bajo anestesia obteniendo muestras de corazón e hígado. Resultados: Se encontró aumento de la concentración sérica de GOT en el grupo experimental comparado con el control. El análisis histológico que evaluó congestión vascular, necrosis y edema en ambos tejidos, reveló que el corazón tenía mayor daño que el hígado. Conclusión: El tejido cardiaco presenta mayor daño que el tejido hepático por consumo de BE en ratas Holtzman macho, manifestados por incremento de GOT y alteraciones histopatológicas. Palabras clave: Bebidas energéticas, transaminasas glutámicas oxaloacéticas (GOT), daño cardiaco, daño hepático. SUMMARY Objective:The energy drinks (EDs) consumption is rising, mainly amongst young people because they promise to improve alertness and improves physical and cognitive performance, and avoid fatigue. In our country, an ED has high caffeine and sugar levels per bottle, and highly commercialized and cheap. However, these beverages have side effects such as cardiovascular, neural and gastrointestinal complications. The researches indicate a major damage in the heart and liver by GOT serum high levels and tissue injury. The research aim is to know if the heart or liver is the most damaged organ by ED consumption in Holtzman rats. Methods: 32 male Holtzman rats were randomly categorized into two groups with different oral administration treatment. The Group 1 (Control) received drinking water and the Group 2 (Experimental) received energy drink 5,49 ml /260 g; both groups per 30. An acclimation week including rat food was provided. During the experimental period there were four blood extractions since the onset to the final for serum GOT analysis. The rats were sacrificed by exsanguination under anesthesia and samples of the heart and liver were harvested. Results: Our results show serum GOT concentration inc...
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