regarding not only cerebral but abdominal or renal tissue oxygenation (rSO2) as well. Fractional tissue oxygen extraction (FTOE) is calculated from NIRS measurements and arterial haemoglobin oxygen saturation (SpO2) measured by pulse oxymeter. Multichannel NIRS devices maybe very helpful in newborns with multisystem problems enabling realtime simultaneous measurements of rSO2 from different parts of the body. Pulse oxymeter integrated into a multichannel NIRS device provides simultaneous SpO2 monitoring making FTOE calculations more accurate and easier. Methods Three term newborns; 2 undergoing therapeutic hypothermia for hypoxic ischaemic encephalopathy grade II, 1 with critical pulmonary stenosis before and after cardiac surgery were monitored by multichannel NIRS (Sensmart X-100, NONIN, USA) device including cerebral, abdominal, renal rSO2 and SpO2 probes. FTOE was calculated using the equation; (SpO2-rSO2)/SpO2. Results Duration of monitorization and rSO2 and FTOE values of different body sites are presented in table with mean±SD. Discussion Longterm simultaneous monitoring of tissue oxygenation in brain, abdomen and kidneys is useful while following newborns with multisystem problems requiring hypothermia or circulatory medications to titrate the treatment accordingly. NIRS device with integrated pulse oxymeter maybe helpful for realtime calculation of FTOE to assess hemodynamics.

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36 weeks GA increased significantly in infants 1,000-1,500 g and head circumference at 36 weeks GA increased significantly in all infants. No significant differences were seen in the rates of NEC, BPD, ROP, IVH and PVL. Conclusions Modified nutritional protocol based on supplying the early aggressive macronutrients and higher calorie, can significantly reduce the incidence of EUGR in infants ≤1,500 g without any complications. We need further investigation to improve growth in infants <1,000 g. Background and aims Very low birth weight (VLBW) infants have a greater risk for the oxidative stress related diseases (OSRDs) like retinopathy of prematurity, bronchopulmonary dysplasia, periventricular leukomalacia and necrotizing enterocolitis. Naturel antioxidant activity of phenols, flavonoid and tocopherols in extra virgin olive oil (EVOO) may be preventive for the OSRDs. The purpose of conducting a randomised controlled pilot study is to compare the weight gaining, length of hospitalisation and the OSRDs of VLBW infants who received early enteral nurtition with and without EVOO support. Methods VLBW newborns were divided into two groups in this pilot study. Group 1 received enteral nutrition and EVOO, Group 2 received only enteral nutrition. Nutritional analysis was undertaken for EVOO that was added as 0.5 ml/day in 100 ml enteral nutrition. Total parenteral nutrition (TPN) and minimal enteral nutrition was initiated both of two groups. Results A total of 26 VLBW infants were divided into two groups (Group 1)(n = 13) and (Group 2) (n = 13) and assessed the birth weight: Group 1= 1,329 ± 35 g, Group 2 = 1,276 ± 32 g. gestational age: Group 1= 31 ± 2.79, Group 2 =29 ± 2 weeks. There was no significant difference between two groups for weight gaining, length of hospitalisation and the OSRDs. Conclusions EVOO is very important natural antioxidant and anti-inflammatory nutrients for preterm infants particularly VLBW. A larger randomised controlled trials are needed to show the antioxidant and anti-inflammatory effects of olive oil for prevention of OSRDs in this high risk group. PO-0588

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