Neurogenic heterotopic ossification (NHO) is a process of benign bone formation and growth in soft tissues surrounding major synovial joints and is associated with central nervous system (CNS) injuries. It is a common complication in major CNS injuries, such as traumatic brain injury, spinal cord injury, and stroke. Here, we report the case of a 72-year-old male, who experienced a traumatic brain injury and painful chronic NHO around the left hip joint. Three applications of extracorporeal shock wave therapy (ESWT) were administered to the area of NHO, which resulted in pain relief and an improvement in the loss of motion in the left hip joint. Improvements were also noted in walking performance and activities of daily living, although the size of NHO remained unchanged. Therapeutic effects of ESWT lasted for 12 weeks.

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Objective We conducted a meta-analysis to determine the effectiveness of selective serotonin reuptake inhibitors in improving motor outcomes after stroke. For accuracy, we only included studies in which selective serotonin reuptake inhibitors were administered to patients in the recovery phase after stroke (<6 mos after stroke). Design Meta-analyses were conducted according to the tools used to measure motor function. We searched the SCOPUS, PubMed, Embase, and Cochrane Library databases for studies, which compared motor recovery in patients who receive selective serotonin reuptake inhibitor medication in the recovery phase after stroke with a control group that did not receive any selective serotonin reuptake inhibitor. Results A total of 3715 publications were assessed, and nine studies met the study criteria. The group, which received selective serotonin reuptake inhibitors, showed improved Fugl-Meyer Motor Scale and Barthel index scores compared with the control group. However, there was no significant difference in the modified Rankin Scale scores between the selective serotonin reuptake inhibitor and control groups. The incidence of adverse effects after the administration of selective serotonin reuptake inhibitors did not differ from that in the control group. Conclusions Our study showed that the use of selective serotonin reuptake inhibitor in the recovery phase of stroke improved motor function without significant increase in adverse effects.

Objective To investigate the correlation between videofluoroscopic swallowing study (VFSS) and radionuclide salivagram findings in chronic brain-injured patients with dysphagia.Methods Medical records of chronic brain-injured patients who underwent radionuclide salivagram and VFSS were retrospectively analyzed. Patients were divided into two groups according to salivagram findings. Differences in patient characteristics and clinical factors, including Mini-Mental State Examination (MMSE), Modified Barthel Index (MBI), Functional Ambulatory Category (FAC), feeding method, tracheostomy state, and VFSS findings between the two groups were investigated.Results A total of 124 patients were included in this study. There were no significant differences in MMSE, MBI, FAC, feeding method, and presence of tracheostomy between the two groups. However, the incidence of aspiration pneumonia history was significantly higher in the positive salivagram group. The Functional Dysphagia Scale (FDS) was significantly associated with positive salivagram findings, especially in the pharyngeal phase. A multivariate logistic regression analysis showed that laryngeal elevation and epiglottic closure was statistically significant FDS parameter in predicting salivary aspiration on a salivagram (odds ratio=1.100; 95% confidence interval, 1.017–1.190; p=0.018). The receiver operating characteristic (ROC) curve of FDS in the pharyngeal phase showed that an optimum sensitivity and specificity of 55.1% and 65.4%, respectively, when the cut-off value was 39.Conclusion In chronic brain-injured patients, inappropriate laryngeal elevation and epiglottic closure is predictive variable for salivary aspiration. Therefore, performing a radionuclide salivagram in patients with FDS of 39 or less in the pharyngeal phase for prevents aspiration pneumonia from salivary aspiration.

Review question / Objective: We conducted a meta-analysis to determine the effectiveness of SSRIs in improving motor outcomes after stroke. Condition being studied: Stroke is a major cause of disability, and motor weakness is one of the most disabling and common complications of stroke. It impairs patients’ ability to perform daily activities independently and deteriorates their quality of life. Selective serotonin reuptake inhibitors (SSRIs) have been reported to have a positive effect on motor recovery after stroke, as well as on the prevention or management of post-stroke depression. In contrast, some previous studies have revealed no positive therapeutic effects of SSRIs on motor recovery after stroke. In the current study, to accurately determine the effectiveness of SSRIs for improving motor outcomes after stroke, we only included studies in which SSRIs were administered to patients in the recovery phase after stroke (<6 months after stroke onset).