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Reseña de Gerardo Cruz-Grunerth: Eugenia 2218. La visión poshumana de Eduardo Urzaiz. Mérida: Universidad Autónoma de Yucatán, 2022

G-protein coupled receptors have been identified as important factors in melanoma progression including growth and proliferation of tumorigenic cells, as well as facilitating metastasis. Upregulation of the G-protein coupled receptor Endothelin receptor b (Ednrb) and its ligand Endothelin 3 (Edn3) has been implicated in melanoma progression in several ‘in vitro’ experiments. In this study we investigated the putative role of Edn3 over-expression in melanoma progression in vivo. Tg(Grm1) Epv mice over-expressing metabotropic glutamate receptor 1 (Grm1) under the Dopachrome tautomerase promoter that spontaneously produce melanocytic lesions in the ears and tails with limited metastatic capability, were crossed with transgenic mice that over-express Edn3 under the keratin 5 promoter (K5-Edn3). The Tg(Grm1)Epv/K5-Edn3 mice tumors appeared ∼ 3 months earlier and grew at a rate 3-4 times faster than the Tg(Grm1)/Epv control mice. Ninety-five percent of Dct-Grm1/ K5-Edn3 mice also displayed pigmented lesions in distant organs such as the lungs. Real Time PCR analysis showed higher expression levels of angiogenic related genes such as Hif-1α in the Dct-Grm1/K5-Edn3mice, when compared to controls. Our studies demonstrate that Edn3 over-expression enhances melanoma progression to a fully malignant state. Our preliminary data also suggests that Edn3 may be involved in tumor angiogenesis leading to faster melanoma tumor development. Citation Format: Nikeisha L. Chin, Juan Carlos Gallegos, Rosy Cruz, Ruslan Garcia, Andrea Gonzalez, Manuel Borobia, Lidia Kos. Role of endothelin 3 in melanoma progression and metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2819. doi:10.1158/1538-7445.AM2013-2819 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.

Reseña de Adriana Azucena Rodríguez: Permanente fugacidad. Ensayos sobre minificción. México: Universidad Autónoma Metropolitana, 2020.