(1) Background: Clinicians demand new tools for early diagnosis and improved detection of colon lesions that are vital for patient prognosis. Optical coherence tomography (OCT) allows microscopical inspection of tissue and might serve as an optical biopsy method that could lead to in-situ diagnosis and treatment decisions; (2) Methods: A database of murine (rat) healthy, hyperplastic and neoplastic colonic samples with more than 94,000 images was acquired. A methodology that includes a data augmentation processing strategy and a deep learning model for automatic classification (benign vs. malignant) of OCT images is presented and validated over this dataset. Comparative evaluation is performed both over individual B-scan images and C-scan volumes; (3) Results: A model was trained and evaluated with the proposed methodology using six different data splits to present statistically significant results. Considering this, 0.9695 (±0.0141) sensitivity and 0.8094 (±0.1524) specificity were obtained when diagnosis was performed over B-scan images. On the other hand, 0.9821 (±0.0197) sensitivity and 0.7865 (±0.205) specificity were achieved when diagnosis was made considering all the images in the whole C-scan volume; (4) Conclusions: The proposed methodology based on deep learning showed great potential for the automatic characterization of colon polyps and future development of the optical biopsy paradigm.

Colorectal cancer is one of the leading cancer death causes worldwide, but its early diagnosis highly improves the survival rates. The success of deep learning has also benefited this clinical field. When training a deep learning model, it is optimized based on the selected loss function. In this work, we consider two networks (U-Net and LinkNet) and two backbones (VGG-16 and Densnet121). We analyzed the influence of seven loss functions and used a principal component analysis (PCA) to determine whether the PCA-based decomposition allows for the defining of the coefficients of a non-redundant primal loss function that can outperform the individual loss functions and different linear combinations. The eigenloss is defined as a linear combination of the individual losses using the elements of the eigenvector as coefficients. Empirical results show that the proposed eigenloss improves the general performance of individual loss functions and outperforms other linear combinations when Linknet is used, showing potential for its application in polyp segmentation problems.

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According to the study, it seems that TELMA had an attractive design, innovative content and interactive navigation, which are three key features of an e-learning platform. TELMA successfully met the three criteria necessary for consideration as a website of quality by achieving more than 70% of agreements regarding all usability, content and functionality items validated; this constitutes a preliminary requirement for an effective e-learning platform. However, the content completeness, authoring tool and registration process required improvement. Finally, the e-MIS validity methodology used to measure the three dimensions of web quality in this work can be applied to other clinical areas or training fields.