Mode I fracture (tensile type) is the common cracking mode of asphalt pavements, which is caused by thermal cyclic loading or traffic. Some studies allow the analysis of the fracture modes by means of standardized tests, some of which are limited, difficult, with little repeatability or do not generate an adequate tension state. In this paper, mode I fracture toughness of asphalt mixtures with symmetric geometry specimens at intermediate temperature is evaluated. Experimental results from direct tension test and simulations on asphalt mix specimens subjected to intermediate temperatures of 10, 20 and 30 °C, mode I load rates (0.5, 1 and 2 mm/min) and notches (2 and 3 cm) were compared to find the variables that reflect the operating conditions of the asphalt mix. Results showed that shear stresses are 8.12% lower in the simulations with respect to the tests, while the load–deformation curves show 30% and 35% variation, where the temperature of 20 °C, the notch of 2 cm and the loading speed of 1 mm/min are the conditions that best represent the stress state of the test; moreover, it manages to consider the elastic and viscous components of the material.