Introduction: Colonic lipomas are low-risk lesions that require endoscopic or surgical management depending on their size and symptoms. However, diagnosing a lipoma­tous lesion in the colon is a difficult task, as the clinical or imaging findings point to a low prevalence of these lesions and a higher fre­quency in the female sex. The laparoscopic approach is the current method of choice as it represents fewer traumas and, therefore, a faster clinical recovery.Case presentation: 43-year-old female patient, Caucasian, from the city of Bogotá, housewife, without any medical history. She presented with acute abdominal pain associated with tarry stools. Diagnostic imaging tests were performed, finding colo-colonic intussusception, originated in a lipomatous lesion located in the transverse colon. This patient underwent an enlarged lap­aroscopic right hemicolectomy.Discussion: This case describes how colonic intussusception constitutes a preoperative complication that requires surgical management since its diagnosis considering the associated mortality rates.Conclusion: The analysis of this case is part of the scientific evidence indispensable to im­prove the diagnostic and therapeutic approach to colonic intussusception, as local and in­ternational literature have not addressed this condition sufficiently.