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Background:To analyze the influence of the histopathologic features in patterns of recurrence in patients with locally advanced gastric cancer Methods: This is a retrospective study of 322 resected locally advanced gastric cancer patients, analyzing the influence of histopathologic characteristics of the tumor in relation with patterns of disease failure. All patients had serosal involvement, with or without lymph node invasion, and absence of distant metastasis. One hundred and four patients underwent curative resection, with added following inclusion criteria: no macroscopic residue after resection, resection margins and no more than 15 infiltrators isolated lymph nodes in the surgical specimen. Thirty eight patients who died in the post-operative period were excluded from the analysis. Statistical comparison were made using Chi squared test, "t" test and U Mann-Whitney test and multiple logistic regression. Results: The total failure rate was 50% (163/322), with locoregional failure at 29% (93/322) and distant failure at 43% (141/322). One hundred forty-five patients (90%) had failure in the abdomen while 13 (8%) had extra-abdominal metastasis. Patterns of failure were