The main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and are a model for the study of the interactome due to its conserved function in the regulation of different biological processes such as immunity and development throughout the metazoan. Herein, three visual artists and a music professor collaborated with scientists for the functional characterization of the AKR2 interactome in the regulation of the NF-κB pathway in human placenta cells. The results served as a methodological proof-of-concept to advance this research area. The results showed new perspectives on unexplored characteristics of AKR2 with functional implications. These results included protein dimerization, the physical interactions with different proteins simultaneously to regulate various biological processes defined by cell type-specific AKR–protein interactions, and how these interactions positively or negatively regulate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway in a biological context-dependent manner. These results suggested that AKR2-interacting proteins might constitute suitable secondary transcription factors for cell- and stimulus-specific regulation of NF-κB. Musical perspective supported AKR/SUB evolutionary conservation in different species and provided new mechanistic insights into the AKR2 interactome. The combined scientific and artistic perspectives resulted in a multidisciplinary approach, advancing our knowledge on AKR/SUB interactome, and provided new insights into the function of AKR2–protein interactions in the regulation of the NF-κB pathway. Additionally, herein we proposed an algorithm for quantum vaccinomics by focusing on the model proteins AKR/SUB.

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No hay duda de que las obras cervantinas reflejan con fidelidad el mundo musical de finales del XVI y principios del XVII: instrumentos musicales, danzas, bailes, romances y canciones son con frecuencia citados y representados en sus páginas con el fin no ya sólo de describir el entorno pintoresco en el cual cobran vida sus personajes –tal y como sucede en el mundo gitano de Preciosa o, por ejemplo, en las tradiciones musicales musulmanas representadas en La gran sultana o Los baños de Argel– sino con la voluntad de añadir un valor semántico especial que tal vez fuera comprendido por los lectores-oyentes de principios del XVII. Este artículo trata pues de analizar el tópico musical “De la dulce mi enemiga”, una canción bien conocida que contó con múltiples realizaciones musicales y que sin duda opera en distintos niveles sobre los textos cervantinos como una referencia musical implícita portadora de un sentido único y revelador.

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