Nowadays, due to emerging developments in the oral drug delivery systems several newer technologies are come out. Oral route of administration has achieved much more popularity because of its ease in administration. There are various dosage forms those can be administered orally. Out of which, chewing gum is most popular. It is a potentially useful means of administering drugs locally and systemically. In recent years the medicated chewing gum has gained increasing acceptance as a drug delivery system. Chlorhexidine gluconate is antibacterial agent used for management of tooth decay. In mouth, Chlorhexidine gets readily adsorbed to negatively charged area, including mucosa and pellicle coated teeth. Chlorhexidine remains bacteriostatically active also after adsorption. In this formulation chewing gum release the active ingredient into the saliva up to the time as the gum product is masticated. In present work chewing gum formulations were prepared by synthetic gum base and by using different Plasticizers such as Castor oil, Glycerin and dibutyl phthalate. Glycerin batch shows best result than castor oil as well as dibutyl phthalate.