We present a new gauge for asymptotically flat spacetime that treats future and past null infinities (I + and I − ) democratically. Our gauge is complementary to Bondi and Ashtekar-Hansen gauges, and is adapted to the S-matrix being the natural observable. One new feature is that the holographic directions are null. We present a set of consistent fall-offs in terms of null coordinates at both I + and I − , with finite BMS ± charges. The diagonal BMS 0 symmetry of the gravitational S-matrix emerges upon demanding asymptotic CPT invariance. Trivial diffeomorphisms, (absence of) log fall-offs, possible enhancements of BMS algebra, and the possibility of holographic renormalization of data at I + − and I − + , play interesting roles. Gory details of the various new technical features that emerge, are elaborated in a companion paper to this letter.

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Music therapy academic faculty responsible for teaching the next generation of healthcare practitioners have a special responsibility to ensure that the learning environment is one in which the principles of equity and inclusion are upheld and practiced. When LGBTQ+ content is unavailable in the educational environment, it marks the presence of overt and covert hostility and microaggressions toward LGBTQ+ people and their identities. The classroom then exists as a heteronormative and cisnormative space that places the burden on students to discover, include and manage reference to LGBTQ+ identities and experiences.   Socially constructed roles which relied on limited conceptions of a normative binary that recognized only hetero and cis male and female identities is shifting; LGBTQ+ people are increasingly reflected in the media and our society, creating opportunities for deep thinking and expansion. Reviewing current teaching environments and methods allows consideration of the kinds of social constructions that limit our capacity as educators and music therapists to fully include LTBTQ+ people and content. In this paper, two LGBTQ+ relatively recent music therapy graduates and two hetero cis seasoned feminist music therapy educators use anti-oppressive practice theory to reflect on and reveal predominant heteronormative and cisnormative values in music therapy education and reflect on ways to make classroom and practicum settings a safe and exploring space for all students and their clients.

Familial dysautonomia is an autosomal recessive genetic disease found almost exclusively among Ashkenazi Jews, characterized by deficits in autonomic, sensory, and central functions. Although the gene has been localized to chromosome 9, the biochemical defect remains elusive. We previously reported an increase in globotriaosylceramide in dysautonomic fibroblasts and lymphoblasts, and unusual fibroblast growth patterns suggesting plasma membrane abnormalities. Globotriaosylceramide is a plasma membrane component, and the natural receptor for verotoxin derived from E. coli. In Vero and HeLa cells, which are susceptible to verotoxin, the expression of globotriaosylceramide on the cell surface is maximal at the G1/S boundary of the cell cycle. Measurement of toxin binding at 0 degrees C at this boundary is indicative of the amount of globotriaosylceramide exposed on the cell surface. Above 0 degrees C, verotoxin enters, and is toxic to, the cell. We analyzed verotoxin-globotriaosylceramide interactions in synchronized FD and normal cells at this boundary. 125I-toxin binding was much more marked to lymphoblasts from patients than from controls. When cells were grown in the presence of verotoxin, at 10(-2)-10(-7) micrograms/mL, 70% of dysautonomic lymphoblasts died, compared to 25% of controls. The CD50 was 10 ng/mL for dysautonomic fibroblasts vs 450 for controls. These results may be exploited to create a biological assay to differentiate between FD and normal cells.