A Quick Test of Cognitive Speed was administered to 357 participants without cognitive impairment, aged 18 to 85 years, to explore the effects of age on processing speed variables in Spanish speakers and to provide normative data for the test adapted to this population. Results were consistent with previous findings: correlations between age and naming times were high and statistically significant. Linear regression indicated that cognitive processing speed on this test slows 2 to 4 sec. per decade, depending on the task. Normalized data were provided. The findings concur with several studies that have linked age-cognitive impairment with slowing processing speed. This study attempted to assess the importance of this relation, as information processing speed could be considered a measure of cognitive impairment in everyday clinical screening evaluations.

Criteria for the diagnosis of Alzheimer's disease were established in 1984 by the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's Disease and Related Disorders Association (ADRDA). Commonly used since their implementation, these criteria are becoming obsolete for everyday practice, and a review is being claimed. Three groups of experts consisting of renowned experts from the National Institute on Aging (NIA) and the Alzheimer's Association proposed a set of recommendations to modify the criteria in this field of research. Two notable differences from the initial criteria were included: the incorporation of biomarkers and the formalization of different disease stages in the diagnostic criteria. From now on, mild cognitive impairment is incorporated in the diagnosis as another stage of dementia. However, the new criteria are still under revision and are currently of use for research purposes with the aim to get the definitive modification for the clinical criteria. This chapter presents the main developments in research concerning Alzheimer's disease and mild cognitive impairment to define these new research criteria.

This case study aims to describe the application of the Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders in the case of a 30-year-old patient with a diagnosis of Ultra-high Risk for Psychosis (UHR) and comorbid anxiety and depression. UP is a psychological intervention that uses cognitive-behavioral techniques whose objective is to reduce emotional dysregulation, which is one of the transdiagnostic mechanisms of emotional disorders. UP has demonstrated its efficacy in samples of patients with emotional disorders. Frank was a 30-year-old man diagnosed with UHR and other emotional disorders (major depressive disorder, bulimia nervosa, generalized anxiety disorder, and social anxiety disorder) who underwent the UP intervention in 15 group and online sessions, lasting 2 hours each, over the course of 4 months. At the 6-month follow-up evaluation, Frank presented significant improvement in all emotional and functioning variables: anxious and depressive symptoms, negative and positive affect, neuroticism and extraversion, emotional dysregulation, maladjustment, and quality of life. There was also a reduction in subthreshold psychotic symptoms. Frank no longer met the criteria for any emotional disorder. We also found an improvement trend, although not significant, in other variables such as insight and cognitive biases measured with specific questionnaires for psychosis. Frank attended all treatment and follow-up sessions and rated the program very positively. UP may be a clinically useful treatment for young people with comorbid UHR and emotional disorders in the early stages of mental health illnesses that could improve clinical and functional outcomes.